Abstract
Medicinal hemp (Cannabis sativa L.) has gained global attention due to its high-value phytocannabinoids, particularly cannabidiol (CBD) and tetrahydrocannabinol (THC), which exhibit significant therapeutic potential. Protected cultivation offers a climate-resilient and sustainable strategy to optimize hemp production by controlling environmental factors, ensuring year-round supply, and improving quality attributes. This paper outlines the key principles and technologies for protected hemp cultivation, including light spectrum management, temperature and humidity control, CO2 enrichment, nutrient and water management, pest and disease suppression, and post-harvest handling techniques. Advanced greenhouse and indoor production systems enable precise regulation of microclimate, reduce crop losses, and enhance cannabinoid and terpene profiles compared to open-field production. The integration of smart technologies and autonomous control systems can further enhance operational efficiency and consistency. The paper concludes that protected cultivation systems represent an effective approach to overcome climatic uncertainties and meeting the increasing demand for medicinal hemp production on sustainable grounds.